Amber Technology's Reference Center

Rose Hips

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12880322&dopt=Abstract

Department of Food Science, Danish Institute of Agricultural Sciences, Research Centre Aarslev, Kirstinebjergvej 10, DK-5792 Aarslev, Denmark.

The galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-beta-d-galactopyranosyl glycerol (1) isolated from dried and milled fruits of Rosa canina by bioassay-guided fractionation is an antiinflammatory agent with inhibitory effects on chemotaxis of human peripheral blood neutrophils in vitro. The inhibition of cell migration is not related to toxicity. The presence of 1 in rose hips may explain the clinically observed antiinflammatory properties of rose hip herbal remedies.

http://www.drugdigest.org/DD/PrintablePages/herbMonograph/0,11475,552452,00.html

Because fresh rose hips contain significant amounts of vitamin C, which is also known as ascorbic acid, they have been promoted for the prevention and treatment of the common cold. While no scientific evidence supports the theory that large doses of vitamin C can increase the body's resistance to colds or any other conditions, their high content of vitamin C and other nutrients such as folate makes rose hips a common ingredient in multiple vitamin products. The amount of nutrients in rose hips depends on the species of rose and on the growing conditions. In addition, their vitamin C content decreases with drying, processing, and storage; therefore, commercially available "natural" vitamins containing rose hips frequently also include vitamin C from synthetic sources.

Some recent evidence from animal studies suggests that an extract of rose hips may have a protective effect on stomach tissue. Extracts are concentrated liquid preparations usually made by soaking chopped or mashed plant parts in a liquid such as alcohol, and then straining out the solid parts. In one study involving laboratory rats, rose hip extract protected against all experimentally-induced stomach ulcers. More study is needed to prove or disprove this finding.

Rose hips have been used in the past to treat diarrhea. They contain a small percentage of tannins, which provide mild astringent properties. An astringent shrinks and tightens the top layers of skin or mucous membranes, thereby reducing secretions, relieving irritation, and improving tissue firmness -- all actions that may help relieve diarrhea. Rose hips may also have mild diuretic effects, meaning that they may promote the loss of water from the body. This possible diuretic action is thought to result from pectin and small amounts of natural fruit acids contained in rose hips. Studies of laboratory animals, though, show that the diuretic action of rose hips is both minor and unpredictable. Prescription and non-prescription drugs are more effective and reliable as both antidiarrheals and diuretics.

Aldworth SJ. Trees and Shrubs of the Iowa State University. 1998. Available at: http://project.bio.iastate.edu/trees/campustrees/Rosa/Rosa_info.html. Accessed July 16, 2003.

Anesini C, Perez C. Screening of plants used in Argentine folk medicine for antimicrobial activity. Journal of Ethnopharmacology. 1993;39(2):119-128.

Anon: Rose hips. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. January 1999.

Carroll J. Growing and harvesting rose hips. No date given. Available at: http://www.apinchof.com/rosehips1086.htm. Accessed July 16, 2003.

Daels-Rakotoarison DA, Gressier B, Trotin F, Brunet C, Luyckx M, Dine T, Bailleul F, et al. Effects of Rosa canina fruit extract on neutrophil respiratory burst. Phytotherapy Research. 2002;16(2):157-161.

Demir AU, Karakaya G, Kalyoncu AF. Allergy symptoms and IgE immune response to rose: an occupational and an environmental disease. Allergy. 2002;57(10):936-939.

Grant A. Therapeutic benefits of roses. Rose Magazine. No date given. Available at: http://www.rosemagazine.com/pages/therapeutic.asp. Accessed July 16, 2003.

Grases F, Masarova L, Costa-Bauza A, March JG, Prieto R, Tur JA. Effect of "Rosa Canina" infusion and magnesium on the urinary risk factors of calcium oxalate urolithiasis. Planta Medica. 1992;58(6):509-512.

Gurbuz I, Ustun O, Yesilada E, Sezik E, Kutsal O. Anti-ulcerogenic activity of some plants used as folk remedy in Turkey. Journal of Ethnopharmacology. 2003;88(1):93-97.

Hvattum E. Determination of phenolic compounds in rose hip (Rosa canina) using liquid chromatography coupled to electrospray ionisation tandem mass spectrometry and diode-array detection. Rapid Communications in Mass Spectrometry. 2002;16(7):655-662.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Larsen E, Kharazmi A, Christensen LP, Christensen SB. An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro. Journal of Natural Products. 2003;66(7):994-995.

Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y. Criteria and recommendations for vitamin C intake. Journal of the American Medical Association 1999;281:1415-1423.

Ozcan M. Nutrient composition of rose (Rosa canina L.) seed and oils. Journal of Medicinal Food. 2002;5(3):137-140.

Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: Stonesong Press; 1999.

Shiota S, Shimizu M, Sugiyama J, Morita Y, Mizushima T, Tsuchiya T. Mechanisms of action of corilagin and tellimagrandin I that remarkably potentiate the activity of beta-lactams against methicillin-resistant Staphylococcus aureus. Microbiology and Immunology. 2004;48(1):67-73.

Stralsjo L, Alklint C, Olsson ME, Sjoholm I. Total folate content and retention in rosehips (Rosa ssp.) after drying. Journal of Agricultural and Food Chemistry. 2003;51(15):4291-4295.

Szentmihalyi K, Vinkler P, Lakatos B, Illes V, Then M. Rose hip (Rosa canina L.) oil obtained from waste hip seeds by different extraction methods. Bioresource Technology. 2002;82(2):195-201.

Traxer O, Huet B, Poindexter J, Pak CY, Pearle MS. Effect of ascorbic acid consumption on urinary stone risk factors. Journal of Urology. 2003;170(2 Pt 1):397-401.

Unlu M, Sahin U, Yariktas M, Demirci M, Akkaya A, Ozturk M, Orman A. Allergic rhinitis in Rosa domescena cultivators: a novel type of occupational allergy? Asian Pacific Journal of Allergy and Immunology. 2001;19(4):231-235.

VanderJagt TJ, Ghattas R, VanderJagt DJ, Crossey M, Glew RH. Comparison of the total antioxidant content of 30 widely used medicinal plants of New Mexico. Life Sciences. 2002;70(9):1035-1040.

Yoshida T, Chen XM, Hatano T, Fukushima M, Okuda T. Tannins and related polyphenols of rosaceous medicinal plants. IV. Roxbins A and B from Rosa roxburghii fruits. Chemical and Pharmacology Bulletin (Tokyo). 1987;35(5):1817-1822.

http://www.herbalgram.org/herbclip/review.asp?i=44463

Winther K, Apel K, Thamsborg G. A powder made from seeds and shells of a rose hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled trial. . Scand J Rheumatol. 2005;34:302-308.

1. Larsen E, Kharazmi A, Christensen LP, Christensen SB. An anti-inflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro. J Nat Prod 2003 Jul;66(7):994-5.

2. Warholm O, Skaar S, Hedman E, Molmen HM, Eik L. The effects of standardized herbal remedy made from a subtype of Rosa canina in patients with osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial. Curr Ther Res, Clin & Experimental. 2003;64(1):21-31.

3. Rein E, Kharazmi A, Winther K. A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits); reduces pain and improves general wellbeing in patients with osteoarthritis -- a double-blind, placebo-controlled randomised trial . Phytomed. 2004;11:383-391.